Quinolinic Acid in the Cerebrospinal Fluid of Children After Traumatic Brain Injury

Citation:

Bell MJ, Kochanek PM, Heyes MP, Wisniewski SR, Sinz EH, Clark RSB, Blight AR, Marion DW, Adelson PD: Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury. Critical Care Med 27(3):493-497, March 1999.

Abstract

Notes:

• Cerebrospinal fluid (CFS) quinolinic acid concentration progressively increased after injury.
• Infants suffering from shaken baby syndrome had increased admission CSF quinolinic acid concentrations compared with children injured in accidents.
• The mechanism of shaken baby syndrome appears to have a unique pattern of CSF quinolinic acid concentrations.
• The study included 17 children. Three were victims of shaken baby syndrome (documented by confession of the perpetrator). The others had been accidentally injured.
• "Our observation that children with shaken infant syndrome show early increases in CSF quinolinic acid concentration after traumatic brain injury (TBI) could reflect a delay in seeking medical attention for these infants or the possibility that they suffered multiple brain injuries produced over an undefined time period."

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