Delayed White Matter Injury in a Murine Model of Shaken Baby Syndrome

Citation:

Bonnier, C, B. Mesples, S. Carpentier, D. Henln, P. Gressens: Delayed white matter injury in a murine model of shaken baby syndrome. Brain Pathology 12(3):320-328, July 2002.

Abstract

Notes:

• Shaking immature mice resulted in injuries like those seen in SBS.
• There is evidencde that excess release of glutamate has something to do with lesions.
• The plasticity and properties of a developing brain are markedly different from adult brains.
• "No clinical evidence of hypoxia-asphyxia was observed during or after shaking."
• 54 of 200 shaken mice died between the 28th and 31st day after shaken.
• Animals that spontaneously died were generally lethargic at the time of death.
• Retinal hemorrhages were found in 1/3 of eyes from shaken mice.
• "A striking finding from our study is that the white matter lesions and thinning associated with shaking became detectable only after some days.... On the other hand, human infants who die following severe shaking do not exhibit a symptom-free interval." Note: According to whom? The assertion that human infants do not exhibit a symptom-free interval is assumption and is not based on any verifiable or falsifiable evidence.